Title
Building Biology In Silico: Spiking Neural Networks as Windows into Disease
Abstract
Computational modeling allows researchers insights into the underlying mechanisms producing a broad range of behavioral outputs. However, traditional approaches using mathematical and rate-based models are unable to capture the temporal features of neural circuits. This gap is particularly consequential when modeling neurodegenerative disease because degeneration alters circuit dynamics in a nonlinear manner that depends on the timing and interactions of multiple neuronal populations. Spiking neural networks (SNNs) address this gap by mimicking the varied and changing spiking patterns of individual neurons, capturing spike timing through membrane potential dynamics.
In this talk, I will introduce our research using SNNs to model the spinal locomotor circuits driving rhythmic movement and their breakdown during amyotrophic lateral sclerosis (ALS). ALS is a fatal neurodegenerative disease marked by the progressive loss of connectivity, interneurons, and motor neurons within spinal locomotor circuits. By simulating the pattern of synapse and cell loss observed in mouse models of ALS, our model allows us to predict optimal windows for intervention, estimate the impact of candidate treatments, and assess the vulnerability of different neuronal populations. In this way, spiking models not only simulate disease, but also generate testable hypotheses experimentalists can use for targeted investigations in animal models.
Bio
Beck Strohmer, PhD is a computational neuroscientist building spiking neural networks to study the breakdown in locomotion during neurodegenerative disease. Beck holds an MSc in Electrical Engineering and a PhD in Neuromorphic Engineering and has developed their research direction exploring the underlying mechanisms of locomotor deficits over their postdoctoral positions.
Speaker is presenting in person from Tromsø.
Practical
The Tuesday Seminar Series covers a range of topics relevant to Integreat’s research focus. Presenters from within and beyond the Integreat community give 40-minute presentations, followed by group discussions.
Seminars are open.
For those unable to attend in person: https://uio.zoom.us/j/65632027408
Point of contacts:
- Organiser and moderator: Veronica Lachi, University of Tromsø
- Integreat Administrative Leader Maria Dikova, University of Oslo